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What's Old?
1926
·Some scientists believe HIV spread from monkeys to humans between 1926 - 1946. Recent research indicates HIV most probably first jumped from chimpanzees to humans as early as and didn't establish itself as an epidemic strain in Africa until 1930.

1959
· A man died in the Congo in what now say was the first proven AIDS death.

1978
·Gay men on the east and west coast, and heterosexuals, begin showing signs of what will later be called AIDS.

1979
- Epidemic begins to spread.

1980
· Deaths in US -- 31 (includes all known cases 1981 and before)

1981
(USA) notices an alarming rate of a rare cancer (Kaposi's Sarcoma) in otherwise healthy gay men. They first call the disease "gay cancer" but soon rename it GRID ("gay-related immune deficiency").
· The New York Times publishes its first article on AIDS,
· 422 cases diagnosed in the U.S.; 159 are dead.

1982
· The etiology of the underlying immune deficiencies seen in AIDS cases is HIV.
· The term AIDS is used for the first time.
· US President Ronald Reagan has not mentioned the word "AIDS" in public yet.
· AIDS is founded in New York City.
· 1,614 cases of AIDS diagnosed in the U.S.; 619 are dead..

1983
· CDC (USA) warns blood banks of a possible problem with the blood supply.
·(France) finds the virus (HIV).
· US President Ronald Reagan has not mentioned the word "AIDS" in public yet.
· 4,749 cases of AIDS in the U.S.; 2,122 are dead.

1984
· Dr. Robert Gallo discoveres the virus that causes AIDS; however, this is about a year after the French discovery.
· US President Ronald Reagan has not mentioned the word "AIDS" in public yet.
· BBS is released, becoming the first mainstream software system to donate 100% of its proceeds to AIDS care/research.
· 11,055 cases of AIDS diagnosed in the U.S.; 5,620 are dead, including --
· (US) approves the first HIV antibody test. Blood products begin to be tested in the US and Japan.
· The first International Conference on AIDS is held in Atlanta (US).
· US President Ronald Reagan has not mentioned the word "AIDS" in public yet.
· AIDs is founded in Los Angeles.
· The first AIDS-related play -- The Normal Heart, by Larry Kramer -- opens in New York.
· 22,996 cases of AIDS diagnosed in the U.S.; 12,592 are dead, including film star.

1986
· US Surgeon General Everett Koop publishes a report on AIDS. It calls for sex education.
·Switzerland begins testing of blood products.
· US President Ronald Reagan has not mentioned the word "AIDS" in public yet.
· AIDS is founded in New York City.
· 42,255 AIDS cases diagnosed in the U.S.; 24,669 people are dead.

1987
· AZT (zidovudine, Retrovir®) - becomes the first anti-HIV drug approved by the FDA. The recommended dose is one 100mg capsule every four hours around the clock.
- stops distribution of tainted blood products.
· The US shuts its doors to HIV-infected immigrants and travelers.
· After a six year silence, US President Ronald Reagan uses the word "AIDS" in public for the first time. And, Vice President George Bush is heckled when he calls for mandatory HIV testing.
· A family -- including three HIV-positive sons (hemophiliacs) (Arcadia, Florida, US) have their home torched by an arsonist.
· After an ACT UP demonstration, the FDA announces a two year shortening in the drug-approval process.
· The AIDS Quilt is started in San Francisco (US).
· 71,176 AIDS cases diagnosed in the U.S.; 41,027 people are dead, including --
· Liberace, entertainer (PCP).
·Michael Bennett, Broadway director (Chorus Line).

1988
"Understanding AIDS," a booklet by Surgeon General C. Everett Koop.
· FDA (US) okays importation of non-approved treatment for PWA personal use.
· February 12, was the first AIDS drug to be granted pre-approval distribution status under the new Treatment IND regulations. Trimetrexate was used to treat Pneumocystis carinii pneumonia in AIDS patients who can not tolerate standard forms of treatment.
· US "/news/sc/1988/sc880801.html" against federal workers with HIV.
· On November 21, FDA licensed Intron A and Roferon A (human interferon alpha injection) for the treatment of Kaposi's Sarcoma, a cancer resulting from HIV.
· On November 28, FDA authorized pre-approval distribution of ganciclovir under a treatment IND protocol for the treatment of cytomegalovirus retinitis in AIDS patients.
· World Health Organization designates December 1st as WORLD AIDS DAY
· 106,994 AIDS cases diagnosed in the U.S.; 62,101 people are dead.

1989
· Haiti stops distribution of tainted blood products.
· On February 3, FDA approves drug for use against PCP.
· On June 15, FDA approved NebuPent (aerosolized pentamidine) for the prevention of Pneumocystis carinii pneumonia.
· On June 23, FDA approved Cytovene (ganciclovir) infusion for use in the treatment of cytomegalovirus retinal infections in persons with AIDS.
· On June 27, FDA authorized pre-approval distribution of erythropoietin (EPO) under a treatment IND protocol for the treatment of zidovudine (AZT) related anemia in HIV positive patients.
· On September 28, FDA approved Retrovir (zidovudine, AZT) in syrup formulation.
· On September 28, FDA authorized pre-approval distribution of dideoxyinosine (ddI) under a treatment IND protocol for the treatment of patients with AIDS or AIDS Related Complex who are intolerant to zidovudine (AZT).
· Licensed the first diagnostic kit to detect the presence of HIV-1 by directly detecting the proteins, or antigens, of the virus.
· On October 26, FDA authorized pre-approval distribution of Retrovir (zidovudine, AZT) under a treatment IND protocol for the treatment of pediatric patients with HIV disease.
· After two years of intense ACT UP protests over the price of its drug, AZT, Burroughs Wellcome lowers AZT's price by 20%.
· 149,902 AIDS cases diagnosed in the U.S.; 89,817 are dead, including --

1990
· Ronald Reagan criticized for his neglect of the epidemic while he was president (US).
· GIS is founded by "/ni/topics/MaryE/index.html" and the Sisters Of St. Elizabeth Of Hungary.
· 198,466 AIDS cases diagnosed in the U.S.; 121,255 are dead, including --
· Halston, American fashion designer.
· Keith Haring, artist.
· "/news/ads/1990/ad900268.html", teenager, hemophiliac, AIDS activist.

What's New?
1991
· ddI (didanosine, Videx®) -- -- a nucleoside reverse transcriptase inhibitor, is for use in the USA.
· 10 million have HIV worldwide (WHO). More than a million are in the US (CDC).
· Professional basketball player Magic Johnson tells the world .
·Kimberly Bergalis, who apparently asks the US congress to force health care workers to be tested for HIV.
· 257,750 AIDS cases diagnosed in the U.S.; 157,637 are dead.

1992
· ddC (zalcitabine, Hivid®) -- -- a nucleoside reverse transcriptase inhibitor, is aprroved for use in the USA.
· First clinical trial of multiple drugs is held.
· FDA (US) starts "accelerated approval" -- interim licensing -- to get promising drugs to PWAs faster.
· PWAs Bob Hattoy and Elizabeth Glaser give speeches to the US Democratic National Convention.
· 335,211 AIDS cases diagnosed in the U.S.; 198,322 are dead.

1993
· CDC (US) revises its definitions including new opportunistic infections.
· In the US, the FDA testing for anal sex, saying sodomy is illegal in too many states.
· Four French blood bank officials for allowing HIV-tainted blood into French blood banks.
· Researchers in Europe show taking AZT (monotherapy) early in the disease has no benefits.
· 411,887 AIDS cases diagnosed in the U.S.; 241,787 are dead.·

1994
· d4T (Zerit®) -- a nucleoside reverse transcriptase inhibitor, is aprroved for use in the USA.
· A Benneton advertisement with US Pres. Ronald Reagan with K.S. lesions.
· 478,756 AIDS cases diagnosed in the U.S.; 288,597 are dead, including --

1995
· Saquinavir (Invirase®) -- -- is approved for use in the US. This is the first anti-HIV drug in the protease inhibitor class.
· Germany convicts four of selling HIV-tainted blood.
· US admits it was the French, not Robert Gallo (NIH, US) who discovered the virus that causes AIDS.
· Olympic diver Greg Louganis reveals that he has AIDS.
· 534,806 AIDS cases diagnosed in the U.S.; 332,249 people are dead.

1996

· Japan makes Green Cross Pharmaceutical Corp. for dealing in HIV-tainted blood.
· Researchers show Kaposi's sarcoma is a herpes virus.

·Basketball star Magic Johnson & Heavyweight boxer Tommy Morrison announce they have AIDS.
· California voters passed Proposition 215 (55.7% to 44.3%) to allow medical use of marijuana. Arizona passed Proposition 200 by a much larger margin, 65.3% to 34.7%.
· 548,102 AIDS cases diagnosed in the U.S.; 343,000 people are dead.

1997
Reports first case of probable HIV transmission through kissing.
· Reports annual AIDS deaths dropped in the U.S.
· Approximate total worldwide death count -- 6,400,000.
· Approximate number of HIV-positive people worldwide -- 22,000,000. To put this number in perspective, it is larger than the continent of Australia.

1998
· FDA approves (trade name Ziagen) for the treatment of Human Immunodeficiency Virus-1 (HIV-1) in adults and children.
· AIDS Researcher and his wife, Dr. Mary-Lou Clements-Mann, were killed in the crash of Swissair Flight 111.
· 665,357 AIDS cases diagnosed in the U.S.; 401,028 people are dead.

1999
· FDA granted granted accelerated approval for a new protease inhibitor for use in children four years of age and older and in adults in combination with other antiretrovirals for HIV infection.
· ÆGiS is nominated to UNESCO's "Memory of the World" programme.

2000
· FDA granted granted accelerated approval for a protease inhibitor, for adults and children greater than 6 months of age with HIV.
· FDA granted granted approval for for the treatment of HIV in adults and adolescents.